Formulation and Evaluation of Solid Lipid Nanoparticles of Water Soluble Drug: Isoniazid

The Solid lipid nanoparticles (SLN) of hydrophilic dug isoniazid (INH), a first line antubericular drug are developed and the entrapment efficiency of drug in the SLN has been improved. The poor incorporation of watersoluble drugs is the problem associated with the incorporation of hydrophilic drugs in to SLN. The SLNs were prepared by ethanol injection method using tristearin and phospholipon 80 H using 3 factorial design. Different combinations of tween 80 concentrations and varied sonication time were used to prepare SLN. The two operating variables sonication time and tween 80 concentrations were found to have significant effect on particle size, entrapment efficiency of SLN but not on the drug release. The prepared SLNs were characterized for surface morphology by SEM analysis, entrapment efficiency, zeta potential, FTIR, DSC, invitro diffusion studies. The prepared SLN were spherical in shape and possess mean average size of 164.9nm.As the preparation of SLN suffer from the drawback of poor incorporation of water soluble drugs the present work is focused to assess the various formulation and process parameters to enhance the incorporation of isoniazid in to SLN. The drug solubility in the dispersion medium plays an important role in improving entrapment efficiency. The SLN could be alternate method for delivery for INH with prolonged drug release profiles and better therapeutic effect can be achieved for the treatment of tuberculosis.